Minocycline in Huntington's disease: A pilot study
Identifieur interne : 003A80 ( Main/Exploration ); précédent : 003A79; suivant : 003A81Minocycline in Huntington's disease: A pilot study
Auteurs : Madhavi Thomas [États-Unis] ; Tetsuo Ashizawa [États-Unis] ; Joseph Jankovic [États-Unis]Source :
- [ 0885-3185 ]
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
- Adult, Aged, Caspase Inhibitors, Cognition Disorders (diagnosis), Cognition Disorders (etiology), Enzyme Inhibitors (therapeutic use), Female, Humans, Huntington Disease (complications), Huntington Disease (drug therapy), Huntington Disease (enzymology), Huntington disease, Male, Middle Aged, Minocycline, Minocycline (therapeutic use), Nervous system diseases, Neuropsychological Tests, Nitric Oxide Synthase (metabolism), Nitric Oxide Synthase Type II, Pilot Projects.
- MESH :
- chemical , metabolism : Nitric Oxide Synthase.
- chemical , therapeutic use : Enzyme Inhibitors, Minocycline.
- chemical : Caspase Inhibitors, Nitric Oxide Synthase Type II.
- complications : Huntington Disease.
- diagnosis : Cognition Disorders.
- drug therapy : Huntington Disease.
- enzymology : Huntington Disease.
- etiology : Cognition Disorders.
- Adult, Aged, Female, Humans, Male, Middle Aged, Neuropsychological Tests, Pilot Projects.
Abstract
Minocycline is a caspase inhibitor, decreases inducible nitric oxide synthase (iNOS), and has been shown to delay disease progression in the mouse model R6/2 of Huntington's disease (HD). This safety and tolerability study included 30 patients with HD who were given minocycline over a 6‐month period and underwent assessments every 2 months with laboratory studies, the Abnormal Involuntary Movements Scale, the Unified Huntington's Disease Rating Scale, and the Mini‐Mental State Examination. Minocycline was well tolerated during this study period and no serious adverse events were noted. © 2004 Movement Disorder Society
DOI: 10.1002/mds.20018
Affiliations:
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Ashizawa</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Department of Neurology, University of Texas Medical Branch, Galveston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName></affiliation></author><author><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name><affiliation wicri:level="2"><country xml:lang="fr">États-Unis</country><wicri:regionArea>Parkinson's Disease Center and Movement Disorders Clinic, Department of Neurology, Baylor College of Medicine, Houston, Texas</wicri:regionArea><placeName><region type="state">Texas</region></placeName><placeName><settlement type="city">Houston</settlement><region type="state">Texas</region></placeName><orgName type="university" n="3">Baylor College of Medicine</orgName></affiliation></author></analytic><series><idno type="ISSN">0885-3185</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0885-3185</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Caspase Inhibitors</term><term>Cognition Disorders (diagnosis)</term><term>Cognition Disorders (etiology)</term><term>Enzyme Inhibitors (therapeutic use)</term><term>Female</term><term>Humans</term><term>Huntington Disease (complications)</term><term>Huntington Disease (drug therapy)</term><term>Huntington Disease (enzymology)</term><term>Huntington disease</term><term>Male</term><term>Middle Aged</term><term>Minocycline</term><term>Minocycline (therapeutic use)</term><term>Nervous system diseases</term><term>Neuropsychological Tests</term><term>Nitric Oxide Synthase (metabolism)</term><term>Nitric Oxide Synthase Type II</term><term>Pilot Projects</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>Nitric Oxide Synthase</term></keywords><keywords scheme="MESH" type="chemical" qualifier="therapeutic use" xml:lang="en"><term>Enzyme Inhibitors</term><term>Minocycline</term></keywords><keywords scheme="MESH" type="chemical" xml:lang="en"><term>Caspase Inhibitors</term><term>Nitric Oxide Synthase Type II</term></keywords><keywords scheme="MESH" qualifier="complications" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="enzymology" xml:lang="en"><term>Huntington Disease</term></keywords><keywords scheme="MESH" qualifier="etiology" xml:lang="en"><term>Cognition Disorders</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Neuropsychological Tests</term><term>Pilot Projects</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Chorée Huntington</term><term>Minocycline</term><term>Système nerveux pathologie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Minocycline is a caspase inhibitor, decreases inducible nitric oxide synthase (iNOS), and has been shown to delay disease progression in the mouse model R6/2 of Huntington's disease (HD). This safety and tolerability study included 30 patients with HD who were given minocycline over a 6‐month period and underwent assessments every 2 months with laboratory studies, the Abnormal Involuntary Movements Scale, the Unified Huntington's Disease Rating Scale, and the Mini‐Mental State Examination. Minocycline was well tolerated during this study period and no serious adverse events were noted. © 2004 Movement Disorder Society</div></front></TEI><affiliations><list><country><li>États-Unis</li></country><region><li>Texas</li></region><settlement><li>Houston</li></settlement><orgName><li>Baylor College of Medicine</li></orgName></list><tree><country name="États-Unis"><region name="Texas"><name sortKey="Thomas, Madhavi" sort="Thomas, Madhavi" uniqKey="Thomas M" first="Madhavi" last="Thomas">Madhavi Thomas</name></region><name sortKey="Ashizawa, Tetsuo" sort="Ashizawa, Tetsuo" uniqKey="Ashizawa T" first="Tetsuo" last="Ashizawa">Tetsuo Ashizawa</name><name sortKey="Jankovic, Joseph" sort="Jankovic, Joseph" uniqKey="Jankovic J" first="Joseph" last="Jankovic">Joseph Jankovic</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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